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HumVar (2011/12) contains 22,196 deleterious mutations and 21,151 neutral mutations of which 7,182 and 1,540, respectively, can be mapped to structure.
As expected, the performance (Acc = 0.846, MCC = 0.692) is rather worse than with the SAAPdb data, simply because the size of the HumVar dataset that can be mapped to structure is much smaller than the SAAPdb dataset.
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One hundred and sixty-nine fruit fly phosphorylation sites can be mapped to structured blocks within 99 specific domain hits and 196 mouse phosphorylation sites can be mapped to structured blocks within 119 specific domain hits.
In (b) and (c), the flexibility index of the apo and ligated structures, respectively, is mapped to structure.
For the SNO sites that can be mapped to structurally resolved structures, half of the buried cysteines were surrounded by spatially adjacent charged amino acids.
Finally, we discuss how such a 'hierarchical affordance competition' process can be mapped to brain structure.
With the crystal structures of each of these enzymes available, these SNPs can also be mapped to the structures to determine whether they will cause a change-in-function on the basis of in silico analysis.
Conserved polar residues (black highlights) can be mapped to the structures: an R follows the α-helix a2, the fido motif HisPFx[D/E]G forms a loop connecting the two central α-helices a3 and a4, and the fido motif N[G/K]R forms the N-terminus of α-helix a4.
Another line of reasoning is that when emotion is put into a song, it has to be mapped to a musical structure or expression.
A total of seventeen mutations could be mapped to a protein structure with a sequence identity of 50% or greater, which we then analyzed for their potential impact on protein function.
Every atom in structure A must be mapped to an atom in structure B which has the same element label, charge, unpaired electron count, etc.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com