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In general, TCM is a transient disorder that can be managed with supportive therapy such as angiotensin-converting-enzyme (ACE) inhibitors, beta-blockers, and diuretics [4],[4]].
Mild adverse reactions can be managed with supportive care and discontinuation of the drug.
Although unmanageable AEs indicate intolerance to therapy, many AEs observed with front-line and second-line TKI treatment can be managed with supportive care.
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Typically, influenza positive case patients were managed with supportive care and antibiotics.
These were grade 1 and 2 in all cases, and were managed with supportive care measures.
TKI therapy has a superior safety profile compared with the previous standard of care, interferon-α, and most adverse events (AEs) observed with front-line and second-line TKI treatment are managed with supportive care.
Those with poor Karnofsky performance score (KPS) may be managed with steroids and other supportive measures.
The most common treatment-related AEs reported with axitinib monotherapy in NSCLC include fatigue, anorexia, diarrhoea and nausea, and these can be managed with dose modification and/or supportive treatment [ 30].
The manageable safety profile of ixabepilone supports its clinical utility, as adverse events can usually be managed with a dose reduction or delay, or with appropriate supportive care.
These toxicities can be managed with dose reductions or interruptions, as well as with the start of appropriate supportive care (Table 5).
Arthritis can be managed with proper treatment.
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