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In a report commissioned by the federal government last year, the National Research Council (congress's official advisor on scientific matters) noted that "the instability of levees and potential of one levee failure to affect others are liable to be major issues for achieving any measure of water-supply reliability or ecosystem rehabilitation".
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Safety and reliability are major issues for the ASDEX Upgrade (AUG) pulsed power supply systems.
Inevitable noises and limited computational time are major issues for time-variant matrix inversion in practice.
These are major issues for people who manage enterprise networks.
As Kardashian says, loneliness and isolation are major issues for people with mental health problems.
Nevertheless, low resistance to oxidative degradation and poor low temperature properties are major issues for palm oils to be used as lubricant [3].
Access to both the health care system and the disability system are major issues for our veterans, which makes the reports of "secret lists" all the more alarming.
These are major issues for the schools".
Proper cleaning, maintenance, repair, and attire are major issues for cGMP [ 27].
Certainly there are major issues ahead for the idea.
I don't think it's been a major issue for science today but the danger is it will be a major issue for science in the future.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com