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A high synaptic weight state, once formed, could be maintained with longer inactive intervals (timescale of ∼1 day).
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The observed PFS benefit was maintained with longer follow-up (median 12.5 12.9 months across groups).
In summary, the primary end point of AVAiL (PFS) was met and the magnitude of bevacizumab benefit was maintained with longer follow-up.
Results: Significant PFS prolongation with bevacizumab compared with placebo was maintained with longer follow-up {hazard ratio (HR) [95% confidence interval (CI)] 0.75 (0.64–0.87), P = 0.0003 and 0.85 (0.73–1.00), P = 0.0456} for the 7.5 and 15 mg/kg groups, respectively.
Secondly, to determine if the survival advantage demonstrated in the prescreening era is maintained with longer follow-up, and thirdly, to ascertain if the survival advantage associated with specialist treatment persists after the introduction of screening.
This is illustrated from a different aspect by Fig. 1(C), as it shows that for a given genomic mutation rate per replication, a longer genome can be maintained with a smaller value of f0/ f1 (see the explanation in the caption too).
We also evaluated whether the initial decreasing mortality trend observed in Schleswig-Holstein was maintained with a longer follow-up.
Anticoagulation was maintained with heparin (initial value 300 IU/kg) to keep the activated clotting time longer than 400 seconds.
Additionally, longer-term trials are needed to determine whether the observed gains are maintained with or without continued intervention.
CeMM can be used in a solid or liquid state, it can be stored unused for at least a year, unattended actively growing cultures may be maintained longer than with standard techniques, and standard C. elegans protocols work well with animals grown in defined medium.
Otter board spread may be maintained for longer periods.
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