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Other alternatives to PMI (e.g., lentiviral vectors) are unable to generate high expressing lines that can be maintained over multiple generations [41], and are of limited use.
Stable cultures could be maintained over multiple passages in these conditions.
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Phenotypic characterization of isolated hSMECs confirmed that a myoepithelial cell phenotype consistent with that from other exocrine tissues was maintained over multiple passages of culture.
We next determined whether differential expression of genes identified by microarray was maintained over multiple passages.
Plants were maintained over multiple years by pruning and when necessary making cuttings.
However, data from a prior study indicate that the antiemetic efficacy of the aprepitant regimen is maintained over multiple cycles of chemotherapy.
An extension of this study provides evidence that the protective effect of aprepitant is maintained over multiple cycles (Herrstedt et al. 2005b).
The 7% discontinuations due to lack of efficacy suggests that the therapeutic effect that was maintained over the long-term and over multiple efficacy endpoints was clinically meaningful in the patients who tolerated the drug.
In contrast when information was being maintained over longer durations, as in the multiple-trial conditions, both the transient and sustained BOLD responses were increased.
Given that the correlation was maintained over evolutionary time, we decided to combine data from multiple species to minimize the contribution of noise to our divergence estimates (see Materials and Methods).
However, there are several studies that challenge this concept, with evidence that fibrosis is maintained over a longer period of time following either a single dose or multiple doses of bleomycin [ 7, 10– 10].
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CEO of Professional Science Editing for Scientists @ prosciediting.com