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First, high levels of diversity at PIP genes may be maintained by selective mechanisms - either sensu strictu balancing selection or divergent selection at a local scale, which mimics the effects of balancing selection.
GC-rich elements in 5'UTRs are mostly confined to evolutionarily conserved sequences and could be maintained by selective pressure due to conserved biological function.
Heterogeneous DNA repeats may have emerged by mechanisms other than slippage or they may be maintained by selective pressure for homogeneous amino acid content [ 12].
Indeed, the degree of the polymorphism of Prdm9 is comparable with that of MHC, which may be maintained by selective advantage.
Generally, positive selection may act on beneficial mutations arising within the MHC, and this variation is hypothesized to be maintained by selective forces mediated by pathogen variability and disassortative mating [ 16, 56, 57].
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Resistant P. falciparum haplotypes that predominate in sub-Saharan Africa appear to possess a fitness disadvantage, suggesting that they are maintained by selective pressure from chloroquine, which is still heavily used [ 2, 3].
Thus, if the duplication has been maintained by selection, control of replication may not be the singular or primary selective driving force.
In this study, I propose that the majority of spliceosomal introns in vertebrate genomes may be maintained by a selective force against intron loss: exon definition.
Theory suggests that collaboration can be maintained by repeated interaction of the same partners (partner fidelity) or by selective discrimination against non-cooperative partners (partner choice).
The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts.
Recent studies suggest that the conservation of miRNA 5' termini was maintained by the selective loading of miRNA into the Argonaute complex [34].
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