Great advances have been made in functional Magnetic Resonance Imaging (fMRI) studies, including the use of longitudinal design to more accurately identify changes in brain development across childhood and adolescence.
However, due to technical difficulties, no further progress has been made in functional genomic study and massive novel gene mining in avian PGCs as well as neighboring stroma cells.
After the macronuclear genome was sequenced, substantial progress has been made in functional genomics research on T. thermophila, including genome-wide microarray analysis of the T. thermophila life cycle, a T. thermophila gene network analysis based on the microarray data and transcriptome analysis by deep RNA sequencing.
The abundance of genome information and the ease with which it can now be obtained makes the need eminent for technologies that enable progress to be made in pursuing questions relating to functional genomics.
Although the exact neuro-circuital cascade underlying the divergent imaging findings remains unknown, several hypotheses can be made in the light of previous anatomical and functional studies.
It will be interesting to analyse whether similar observations can be made in human tumour cells, whereby analysis of functional 'ERBB2 dependence' will be more difficult compared to the NIH3T3-HER2 model.
Recently, substantial advances have been made in engineering functional trachea using an artificial matrix and a decellularized, cadaveric scaffold[74, 75].
Since the rice genome was sequenced (Goff et al. 2002; International Rice Genome Sequencing Project 2005; Yu et al. 2002), significant advancements have been made in the functional genomics of this crop.
We can also use this "architecture change" capability to keep the architecture of a system stable when changes are made in the functional requirements.
In the post-genomic era, increasing efforts are being made in plant functional genomics.
