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This result can be explained if LFY is prone to be lost by drift due to a low probability of subfunctionalization or neofunctionalization.
Chance affects the occurrence and fixation of beneficial mutations, as even beneficial mutations can be lost by drift when they first appear, and are very rare [35].
Lack of balancing selection in the other species would allow the ancestral alleles to be lost by drift and shared polymorphisms would not be maintained.
Some introgression blocks may be lost by drift, while others may persist.
Thus, a mutation that confers a 5% advantage, such as the one in BoxG1, is expected to be lost by drift ~90% of the time.
But on this hypothesis, the vast majority of those variants are expected to be of very low frequency and destined to be lost by drift to fixation [ 29].
Similar(54)
The probability of a beneficial mutation being lost by drift is approximately 1 - 2 s, where s is its selective advantage [ 44, 53].
Since the majority of new neutral mutations are lost by drift, 10,000,000 replicate TE insertions were simulated to ensure that TE insertion alleles were retained in ∼10,000 replicates.
By N/10 generations almost all individuals are clustered around S = H I = 0.5, and the population slowly becomes more homozygous as alleles are lost by drift (S remains roughly constant while H I declines toward zero).
On the one hand it is known that positive selection is much more efficient in large populations, since even genes or alleles that provide only a very small advantage are retained in the population rather than being lost by drift.
Overall, our analyses support the hypothesis that C3* Y chromosomes were present in the "First American" ancestral population, and have been lost by drift from most modern populations except the Ecuadorians.
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