However, GI, prophages and RGPs sensu stricto were equally likely to be located in the region of the origin of replication, the replication termination region or other regions.
The last origin of replication should be located in either an EXT repeat or the coding core part of the chromosome.
Two supranumerary open reading frames are present in a large, otherwise unassigned, region, while the origin of replication could be located in a region upstream to the cox3 gene.
In the case of the chromosome, the positive peak for the combined skew is located immediately upstream of the dnaA gene and we predict the origin of replication to be located in the AT rich (69.9 % A + T) intergenic region between the rpmH (LRATCC53608_1967) and dnaA (LRATCC53608_0001) genes.
In contrast, genes for metabolic processes tended to be located in the genomic half that flanks the origin of replication (fig. 3).
Several sequences with predicted functions in programmed cell death and chromosome segregation, replication and chromatin remodelling were found to be located in close proximity to the centromeres.
Viral proteins that are required for the formation of viral replication complexes (VRCs) are often shown to be located in ER [ 34- 36].
In Escherichia coli, chromosome dimers are resolved by two tyrosine recombinases, XerC and XerD, by the addition of a crossover at a specific 28-bp sequence called the dif site, which is located in the replication termination region of the chromosome [ 4, 5].
The ZZ1 seg-like mobile endonuclease (CDS142), which is located in the DNA replication module, has 34 to 54% similarity to 6 seg genes in T4 (segA, segB, segF, segC, segD, and segE).
Within the ∼60 kb strong hotspots, DSB-dependent mutant frequencies are related roughly to the log of the distance between the tet reporter and each I-site, with the exception of tet10, 12 kb from I-site D, which is located in the dif (replication-terminus-proximal) region.
