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In the cerebellar Purkinje neuron (PN), calcium spikes can be elicited by parallel fiber (PF) stimulation and can be localized to small regions [3].
Grid2 is localized to the PC-parallel fiber synapse and is reported to be involved in the maintenance of synapse integrity, as well as long-term depression.
In developing murine cerebellum, vesicular glutamate transporter 1 (VgluT1 encoded by the Slc17a7 gene) that is localized to the excitatory axon terminals of parallel fibers arising from granule cells has been shown to mediate glutamate uptake into synaptic vesicles of Purkinje neurons (Hioki et al., 2003).
In contrast, Syp-GFP is localized to puncta along the ascending segment and the parallel fiber (Figure 4B C), reflecting synaptic connections with Purkinje cells and local inhibitory interneurons.
In a striking parallel with sister chromatid cohesion, proteins of the cohesin complex have been localized to centrosomes and implicated in centriole cohesion in vertebrates, their depletion resulting in centrosome splitting and formation of multipolar spindles [ 3, 22].
– Some words in Help are localized to incorrect language.
While their work is localized to California, it's a wonderful model to follow.
Three MCRs were localized to 1q.
In parallel with our in vitro studies, a punctate distribution of FXa was observed, in accord with the notion that FXa binding is localized to the platelet surface during thrombus formation.
Figure S2 Bim is localized to membranes.
AIF is localized to the nucleus.
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