Call it the Throw Caution to the Wind Principle: If an event cannot be linked with absolute certainty to an underlying trend, both the event and the trend can be safely ignored until it is too late to do anything about it.
Although the underlying mechanism through which histone variants influence gene expression is unclear, certain histone variants have been shown to be linked with specialized genomic roles.
Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown.
Although several environmental factors, such as Helicobacter pylori infection, excessive intake of salt and low intake of vegetables and fruit, have been linked with gastric carcinogenesis, the molecular mechanisms underlying gastric carcinogenesis are poorly understood yet (Peek and Blaser, 2002; Yuasa, 2003).
Primary bacteraemia is linked with a high mortality and is associated with underlying malignancy and immunosuppression, and infection with particular serovars such as Choleraesuis [ 2- 4].
The rate of lipoprotein production has been linked with the availability of PC, but the mechanisms underlying this link are not clear (Vance, 2008; Abumrad and Davidson, 2012).
While the exact mechanism underlying pseudocirrhosis is not fully understood, it has been linked with complications of hepatic encephalopathy, variceal bleeding, and portal hypertension [4].
Although underlying mechanisms have not been completely explained, adipokines have been linked with obesity-induced inflammation and signaling pathways that contribute to type 2 diabetes (1).
