Sentence examples for be linked with mutations from inspiring English sources

In some, but not in all cases, the lack of binding has been shown to be linked with mutations in a cadherin gene [43] [46].

However, we cannot rule out the possibility that these cases may carry germline variations in other genes which could influence breast cancer susceptibility and which include variants within ESR1 that may be linked with mutation status.

Many inherited diseases are linked with mutations in nuclear lamins and integral proteins of the inner nuclear membrane.

It's known that melanoma risk is linked with mutations at particular genetic hot-spots.

TPP is regarded as a model for related conditions, known as "channelopathies", which have been linked with mutations in ion channels; the majority of these conditions occurs episodically.

This finding implies that deafness is linked with mutations in Aspa in Canavan disease.

In both pests, resistance to Cry1Ac is linked with mutations in a gene encoding a cadherin protein that binds Cry1Ac (Morin et al. 2003; Yang et al. 2007).

In humans, inheritable breast cancers have been linked with mutations in the breast cancer susceptibility gene, breast cancer 2 early onset (BRCA2), and the lifetime risk of developing breast cancer is high (81 88 %) in females carrying a BRCA2 mutation [ 7, 8].

AD is genetically heterogeneous and has been linked with mutations in genes encoding amyloid precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) as well as the ε4 allele of apolipoprotein E. Amyloid precursor protein cleavage by the β- and γ-secretase complexes leads to the formation of amyloid-β (Aβ) peptides that can aggregate and form amyloid plaques.

Although no mutations in Kv10.1 have been reported in cancer, high expression of Kv10.1 may be linked with point mutations leading to conformational changes that could affect sensitivity to TA while maintaining intact its oncogenic potential, which is only partly dependent on ion permeation [ 17].

Because some mutations will be linked with the mutator locus, 2 s − Δ U h will be a slight underestimate of the selective disadvantage of a mutator in a sexual population.