Kosik is also emphatic about the benefits of social interaction, citing a study that found that isolation among seniors was linked with cognitive impairment.
Thomas is the youngest and first amateur football player to be found with clear C.T.E., which is linked with cognitive impairment, depression and ultimately dementia.
The work of [82] showed that there are indications that plasma levels of EGF are linked with cognitive decline in Parkinsons disease, indicating it may not be entirely AD-specific as single biomarker.
Poor vitamin B12 status has been linked with cognitive decline [ 28– 30] and AD [ 28, 31, 32].
Three main aspects of the present study add strength to the conclusion that ETS exposure is a neurotoxin that is linked with cognitive deficits.
Although subclinical deficiencies of these nutrients have been reported and have been linked with cognitive outcomes, there does not appear to be a large public health concern about this level of thiamin and riboflavin dietary intakes.
In addition, GH deficiency has been linked with cognitive impairment [ 16, 35, 37], and previous research has shown that Gh expression increases in the rat hippocampus following repeated learning in response to eye-blink conditioning [ 38].
More subtle alterations in hypothalamic-pituitary-adrenal (HPA) axis function have also been linked with cognitive function, with higher plasma cortisol levels at 0900 h being associated with poorer age-related cognitive ability in a small group of elderly, healthy male volunteers (4).
Anatomically, angiotensin II (Ang II) and its receptors are located in neurons inside the blood brain barrier and in the cerebrovascular endothelial cells and circumventricular organs[ 26] Functionally, Ang II has been linked with cognitive function in animal models[ 27] In addition, Ang II also decreases cerebral blood flow[ 28] and impairs neurovascular coupling[ 29] in hypertensive patients.
Several studies in subjects presenting schizotypal features have indicated that the later onset of psychosis is linked with cognitive disorganization and anhedonia [ 26] and a recent follow-up study in 122 non-psychotic subjects investigated the relationship between dimension scores and transition to psychosis during the following 24 months.
