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The Ftind51 mutation may therefore also be linked to virulence in the strain FSC043.
Other molecular attributes that can easily be linked to virulence are type III secretion system components (family rank 10), used by bacteria to secrete directly from the bacterial cell to the host, and heat shock proteins (family rank 8), which can be important for the survival of a bacterium right after it has entered its host.
A number of the genes from this latter set are reported to be linked to virulence in other bacteria.
The oxidative stress response of E. faecalis has been characterized in considerable detail and appears to be linked to virulence [ 71].
Whereas HSI-I is be involved in inter-bacterial interactions through secretion of Tse1, Tse2 and Tse3 [ 75- 77], HSI-II and III could be linked to virulence towards animals and plants [ 78, 79].
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Several other genes were identified that have been linked to virulence or pathogenic potential (Table 4).
In the pathogenic basidiomycete, Cryptococcus neoformans, the MAT locus is linked to virulence [57], [58].
All four mutations found in strain FSC043 have caused disruption of gene functions: all of the disrupted genes in the strain FSC043 have been linked to virulence or have orthologs in F. novicida that have been linked to virulence.
Environmental adaptation traits and stress resistance mechanisms have been linked to virulence, as bacterial survival in the host is often reliant on these factors.
In the strain FSC198, three sthA, ybhO and metA) of the seven genes affected by mutation have been linked to virulence [20] [22].
Short repeat sequences are also found, as well as stem loop sequences that are linked to virulence protein genes [3], complement regulator-acquiring surface protein 1 (CRand_1) and lipoprotein_1 (part of the paralogous gene family termed PFam60).
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