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However, one should be aware that fibrates increase the risk for gallstone formation, a side effect that could be linked to suppression of BA synthesis and that may represent a potential limitation for treatment in patients with biliary damage and an already increased susceptibility to gallstone formation such as PBC.
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In some cases, inhibition of angiogenesis has been linked to suppression of angiogenic factor generation by cells neighbouring the vasculature [3]; [9].
As BMI1 expression has been linked to suppression of the Noxa gene [13], we analyzed naive CD4 T cells stimulated with delta-like 4 to determine if Noxa expression was altered.
Consistently, in cells expressing vinculin-LD, a mutant lacking the interaction with acidic phospholipids, spreading and motility defects were observed, which were linked to suppression of lipid-mediated adhesion site dissolution [21].
If M2-induced cytotoxicity is linked to suppression of the immune response in M2-containing vaccines, then the incorporation of influenza M2 into a vaccination regimen should include the neutralization of its possible negative effects.
For meropenem, the ratio of minimum concentration to MIC (Cmin/MIC) has been linked to suppression of resistance (16).
Symmetric di-methylation of histone H4 at arginine 3 (H4R3me2s) is linked to suppression of gene expression [ 36].
Induction of apoptosis by microtubule-targeted drugs has been linked to suppression of microtubule dynamics and prolonged mitotic arrest.
The premise that activation of EMT is linked to suppression of cellular senescence has been proposed also in the context of another EMT regulator, Zeb1 [ 52].
Various effectors from other nematode species have been linked to suppression of host defences and induction of the feeding site (Haegeman et al. 2012; Hewezi and Baum 2013).
The upregulation of IFITM1 in cancer cells was associated with an increase in migration and invasive capacity, and its action in gastric tumour cells was linked to suppression of NK cells [ 12].
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CEO of Professional Science Editing for Scientists @ prosciediting.com