Sentence examples for be linked to polymorphisms from inspiring English sources
Even the predisposition to psoriasis could be linked to polymorphisms in the TNF α genes promoter, such as −238G G → A polymorphism [ 35 ]. 5q31: in this locus allelic variants for both psoriasis and IBD have been found [ 36, 37 ].
On the other hand, these SCRs show elevated polymorphism [32] indicating that recombination rate might be linked to polymorphism [33] and could represent a mechanism to generate polymorphism providing the raw material for positive Darwinian selection characterising Drosophila immune receptors [28].
Variation in sensitivity to some bitter-tasting molecules has a strong genetic component in humans [12], [18], [19], and in certain cases has been linked to polymorphisms in specific TAS2R receptor genes [4], [5], [20].
24 Decreased susceptibility to lumefantrine has been linked to polymorphisms in these two genes.
Narcolepsy has been linked to polymorphisms in genes encoding the T cell receptor alpha chain [ 42].
They can also contribute to personalized treatment because they are linked to polymorphisms of different populations or individuals.
More recently it has been demonstrated that female pattern hair loss is linked to polymorphisms of the ERβ gene.
Particularly, the inherited long-QT syndrome (LQTS) has repeatedly been linked to polymorphisms of KCNE1 [e.g. [ 6- 8]].
Rare autosomal dominant forms of Parkinson disease in German and Japanese kindred have been linked to polymorphisms in the DUB enzyme known as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) [ 38, 115].
Genetic susceptibility to cardiovascular disease has been linked to polymorphisms of the glucocorticoid receptor gene which in the case of haplotype 3, a common genetic variant, gives rise to a highly active pro-inflammatory system as evidenced by serum C-reactive protein (CRP) which is attributed to diminished sensitivity to cortisol[ 12].
Because incubation periods and altered PrPres deposition in the brain have been linked to polymorphisms in the PrP amino acid sequence (8, 35 ), we investigated the possibility that PrPres biochemical and pathologic changes correlate with different host PrP amino acid sequences.
