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Unlike ion channels observed in bilayers, ADDLs were shown to be linked to neuron toxicity, mostly via binding to protein receptors.
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Activation of microglia has been linked to neuron loss in many neurodegenerative diseases [ 36].
Several other cell cycle regulators have been linked to neuronal plasticity in fully differentiated neurons, such as the anaphase-promoting complex/cyclosome (APC/C) and its activator Cdh1, polo-like kinase 2 (Plk2), Aurora A kinase and the origin recognition complex (ORC) (reviewed in [ 29]).
"In the future, the material could possibly be linked to the neurons and driven by human neuron signals," Wang said.
While the ontology analysis may identify general terms subject to regulation, a manifest focus of our study was to correlate changes in gene expression that can be linked to increased motor neuron excitability and injury-induced spasticity.
The scale of proteome-wide changes described in this report suggests complex molecular and cellular changes in the mdx- 4cv brain that appear to be linked to both progressive neuron degeneration and reactive gliosis.
Together, the observations discussed here suggest that ageing also deleteriously affects spinal neurons that govern bladder/bowel reflexes and continence and that these changes may be linked to ageing of CNS neurons.
Previous studies have concluded that the cerebellum is a site of motor learning [ 29, 30], a mechanism which could be linked to the formation of new neurons or other actions that require neurogenesis-related gene expression.
For more than two decades, researchers have known that the firing of an individual sensory neuron can be linked to the decision that an animal makes about the meaning of the sensory information it has received.
As noted earlier, our studies do indicate that the products of the candidate genes predisposing high alcohol drinking by rats can be linked to the modulation of VTA dopamine neuron function.
ß amyloid's tendency to choke neurons could be linked to an ancient evolutionary mission to protect the brain from pathogens, the authors say.
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