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Reduced PGC-1 α expression is shown to be linked to insulin resistance, type 2 diabetes, and neurodegenerative disease.
The human NAMPT gene maps to a region on chromosome 7q22.2 previously found to be linked to insulin resistance syndrome-related phenotypes in nondiabetic Mexican-Americans [ 12].
Elevated levels of endogenous oestrogen are thought to be linked to insulin resistance and hyperinsulinaemia as a direct result of inhibition of insulin receptor function 119.
Abdominal obesity has been shown to be linked to insulin resistance and hyperinsulinemia [ 15], which has been suggested to underlie the association of obesity and CRA.
Interestingly, we found Bactericidal/permeability-increasing protein (BPI) as a highly ranked candidate and it has been suggested over production of BPI could be linked to insulin sensitivity and glucose tolerance [ 33].
Thus, the discovery of PPAR γ as a master regulator of adipogenesis, the decreased activity of which was also shown to be linked to insulin resistance, was very important.
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On this basis, a mechanism of action of P. virgatus may be hypothesized, which could be linked to insulin-mediated glucose transport transduction pathway in which a series of proteins (phosphatidylinositol-3 kinase, protein kinase C, and PPAR) are involved [ 44, 45].
And other diseases, such as Alzheimer's, appear on Taubes's list, because researchers have studied whether they are linked to insulin resistance.
It is linked to insulin resistance, which may lead to type 2 diabetes, and to an increased risk for cardiovascular disease.
It turns out that excessive consumption of fructose — mostly as high-fructose corn syrup — has been linked to insulin resistance and Type 2 diabetes, so it's not good for diabetics after all.
MED23 has been linked to insulin signaling in the adipogenesis transcription cascade (Wang et al. 2009).
More suggestions(17)
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