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Identification of excipient critical material attributes is not straightforward, as criticality must be linked to functionality and it is well recognized that the mechanisms by which excipients exert their action are not fully understood.
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There is an ever-increasing complexity seen within T lymphocyte populations and phenotype has been linked to functionality and protection; therefore, an understanding of the combination of functions possessed by the T-cell population is needed to effectively assess vaccine efficacy.
The emerging picture is intriguing: structural disorder of arrestin elements appears to be linked to their functionality.
Recent evidence shows that genes mapping in close physical locations in the chromosomes tend to have a high degree of co-expression, that can often be linked to common functionality [ 4].
The dysregulation of these genes in T2D may notably be linked to β-cell functionality, cell death and adaptation to metabolic stress.
Therefore, it is very likely that the decreased RMR, found in old rats, could be linked to changes in the functionality of the two mitochondrial populations that are present in skeletal muscle and that display different activity and differential regulation in response to physiological stimuli [ 6, 7].
On the other hand, the observed interaction with QK1, an RNA-binding protein that regulates mRNA activities, is not known to be linked to any of these functionalities.
We speculate that this tendency to reference functionality may be linked to the common misconceptions that traits arise out of need and that disused traits quickly disappear from populations (Gregory, 2009), but have no data to support this idea.
This reduced functionality of ADH1 appears to be linked to impaired ATP production and less recycling of NAD+.
Epigenetic modifications are linked to the functionality of regulatory elements.
Global transcriptional analysis indicated that MadR1 functionality is linked to lipid editing programs required for growth and persistence.
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