It is thought that only a small percentage of people with autism have mutations in Shank3, but Dr Feng believes many other cases may be linked to disruptions to other proteins that control synaptic function.
Alzheimer's disease has long been linked to disruption in the brain's immune system, but the latest research adds to evidence that inflammation in the brain is not so much caused by the disease, but is a driver of the disorder.
The mechanism of gentamicin action is linked to disruption of ribosomal synthesis of protein, and microbial resistance to gentamicin develops fairly slowly.
Triclosan is associated with carcinogenic byproducts, and is linked to disruption of the thyroid hormone.
There are cases, few and far between thus far, where extreme weight-loss resistance has been linked to disruption of gastrointestinal flora, due to antibiotics or some other trauma.
Perhaps the disease involves the cholinergic system, an idea supported by findings that some human dystonias are linked to disruption of the cholinergic system (Breakefield et al., 2008).
Desensitization has been linked to disruption of the dimer interface between GluA2 LBDs, while stabilization of a symmetrical dimer interface by a mutation (L483Y) reduces desensitization.
Indeed, the production of pro-inflammatory cytokines secreted by resident macrophages in the liver is linked to disruption of hepatic insulin signalling [ 8].
BPA, phthalates, triclosan, parabens and 4NP have been linked to disruption of endocrine pathways and altered hormonal status in both animal and human studies.
Chemicals including bisphenol A (BPA), phthalates, parabens, 4-nonylphenol (4NP) and triclosan have been linked to disruption of endocrine pathways and altered hormonal status in both animal and human studies.
