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These results collectively suggest that increased apoptosis, decreased Treg function and concomitant gene expression changes could be linked to deficient IL-2 secretion from effector T-cells.
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Critically, impaired sleep is common among adolescents [34], and has been linked to deficient striatal recruitment during reward anticipation [35].
This impairment is linked to deficient length-dependent regulation of myocardial function [ 13].
The DRD4 exon III variable number tandem repeat "7 repeats or longer" allele (DRD4 7R+) has been linked to deficient dopamine functioning [ 20, 21].
The impaired memory processes in P2X7R−/− mice could thus be linked to hippocampus-deficient IL-1β synthesis.
To assess whether this feature could be linked to increased ROS production in deficient cells, we analyzed LD in H2O2-treated cells (Fig 7A and B).
The objective of this study was to investigate whether deficient autophagy can be linked to critical illness-induced bone loss.
The low recruitment and activation of CD8+ T cells in the brain of LTβR deficient mice may be linked to a defective production of CXCR3 ligands CXCL9, 10, 11, essential for T cell migration to inflamed tissues, that are reduced in the absence of LTβR [11].
In addition, the clearance of apoptotic cells by macrophages is deficient and could be linked to increased apoptosis [ 6, 7].
The possibility that the delay in TEL-JAK2-induced leukemogenesis observed in RelB-deficient mice could be linked to the inflammatory phenotype of these mice can be excluded since our experiments were performed in the Tcra−/− genetic background, which prevents the development of autoreactive T cells.
This might be explained by a lack of statistical power, or alternatively, deficient synthesis of IL-21 might be linked to COPD exacerbations via other mechanisms.
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