The CPPs were linked to critical quality attributes consisting of the particle size, polydispersity index (PDI), zeta-potential, thermotropic phase behavior, yield and stability.
The CFPs were linked to critical quality attributes (CQAs), which included the intensity-based hydrodynamic particle diameter (z-average), the polydispersity index (PDI), the zeta-potential, the budesonide encapsulation efficiency, the actual budesonide loading and the DOTAP encapsulation efficiency.
HPAA function is linked to critical metabolic tasks such as immune response, cardiovascular function, reproductive physiology, and general well-being [2] [5].
From these results, one should not conclude that 22-kHz calls do not provide important signals for the recipient; rather, one should assume that their salience depends on additional features like a given social context [5], or whether they are linked to critical experiences [59].
Most resource gaps are linked to critical care and include lack of trained personnel and respirators.
The splicing factor Muscleblind-like 1 (MBNL1) is recruited into these foci, causing loss of function of the protein, which has been linked to critical DM1 features [ 89, 91].
SPT performs the initial step in de novo sphingolipid synthesis, catalysing the condensation of l-serine and palmitoyl-coA to form ketosphinganine. Position C133 shows a high degree of evolutionary conservation (Fig. 1A) and lies within a highly conserved protein domain that has been linked to critical roles in SPT activity and substrate specificity (8).
Furthermore, some specific phenotypes in the monosomy 1p36 syndrome — including polymicrogyria (PMG), hyperphagia/obesity, mental retardation, seizures, hearing loss, and periventricular nodular heterotopia (PNH) — have been linked to critical regions within 1p36, each of which nevertheless contains multiple genes [ 2, 4, 9- 11].
It is easy to understand how such knowledge, once it has been definitively acquired by an individual, in so far as it was linked to 'critical' scripts for the preservation of the parent company's competitive advantage, may, ceteris paribus, represent the starting point for the success of the spin-off.
