The hippocampus has been linked to binding processes as well as to conscious recollection of recent events [19], [50].
It could originate from conformational changes, linked protonation, or both, which are linked to binding.
Recently, the signal transduction of MIF has been linked to binding to CD74 and CD44.
Fibroblast recruitment by CXCL10 has also been linked to binding to GAGs instead of CXCR3, in which CXCL10 functions as an antifibrotic chemokine [ 12].
The most abundant groups represented under the molecular function category were linked to binding (34.8%), catalytic activity (27.9%) and structural molecule activity (13.9%).
Similarly, the deciphering of the mouse methylome revealed regions of low methylation at distal regulatory elements, which was linked to binding of tissue specific transcription factors [15] (Fig. 1).
A major subset of ESTs (> 60%) across all libraries was linked to binding and catalytic activity, where the remaining groups involved transporter, signal transduction, transcription factors, secondary metabolism and antioxidant activities.
In the molecular function category, 17,710 and 15,853 unigenes were linked to binding and catalytic activity, respectively; it is worthy of mention that a few genes were assigned to nutrient reservoir activity, metallochaperone activity, channel regulator activity and protein tag (Additional file 2: Figure S2).
Its mechanism of action is linked to binding to the minor groove of DNA and to a variety of modulatory effects on the tumor microenvironment, including changes in the production of several inflammatory mediators like the chemokines CCL2 and CXCL8, the cytokine IL-6 and the angiogenic factor VEGF [ 13].
