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Some scientists have proposed that more than two dozen blood chemicals, taken together, act as biological markers and might be linked to aging.
Similarly, the expression of some miRNAs can be linked to aging [ 53– 53].
This suggests that RNA editing efficiency may be linked to aging in a gene-specific manner (Nicholas et al. 2010).
Literature gives indications that these markers might be linked to aging processes such as oxidative stress, alterations in cell morphology, beta oxidation capacity, and vascular function.
Indeed, the best example of an epigenetic change that may be linked to aging in mammals is decreased expression of sirtuin1 (SIresultinglting in the DNA damage-induced reorganization of chromatin (chromatin instability) (Sommer et al., 2006; Oberdoerffer et al., 2008).
The evidence that miRNAs are present in normal blood, and may be linked to aging, prompted us to carry out a comprehensive assessment of circulating miRNAs in the mouse, in order to observe the effects of age and CR on the levels of these miRNAs.
Similar(54)
Thes story appears in VIcoenzymeine's Burnout andepletionm issue.
A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies.
Yet her telomeres – the ends of chromosomes whose length is linked to aging – were short, reflecting her cell line origins.
Although sirtuins have been linked to aging in a wide variety of organisms, their mechanism of action was understood only in yeast.
Low levels of the molecule have been linked to aging and a wide range of diseases, including type-2 diabetes, Alzheimer's and cancer.
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