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Thus, AtHSFA2, AtHSFA4a, and AtHSFA7a may be linked to activation of different target genes/pathways in the HSR.
Natural antibodies are germ-line encoded molecules that are important in initial recognition of pathogens, circulate in the absence of specific stimulation, and may be linked to activation of the B-cell mediated production of specific acquired antibodies [57], [58].
In [ 33] 34 genes were found to be linked to activation of caspase-3.
The increase of F-actin as stress fibers in cells exposed to Buserelin, strongly suggested that the GnRH/GnRHR system might be linked to activation of RhoA GTPase, which is responsible of stress fiber formation and focal adhesion assembly [ 8].
Previously, it has been demonstrated that vaspin activates Akt via its stimulatory effect on phosphatidylinositol3-kinase (PI3-kinase), which may be linked to activation of endothelial nitric oxide synthase (eNOS), increased production of NO and activation of AMPK [ 19, 20, 24].
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AdipoR1 is ubiquitous, but is most abundantly expressed in skeletal muscle and is linked to activation of AMP-activated kinase (AMPK) pathways.
Direct effects are linked to activation of AMP-activated protein kinase (AMPK) and an inhibition of mammalian target of rapamycin mTOR signaling, and indirect effects are mediated by reductions in circulating insulin, leading to reduced insulin receptor (IR -mediated sIR -mediated
The sensing of larger protein digestion products simulated by, for example meat hydrolysate has been linked to activation of mitogen-activated protein (MAP) kinases, but the receptors involved are less clear [ 35,36].
Therefore, we analysed whether PHD3 activity is linked to activation of caspase-3 and found that PHD3 overexpression increased caspase-3 activity.
76 Furthermore, p53 has been linked to activation of Fas and DR5/KILLER death receptors, which activate the extrinsic apoptosis pathway that also contributes to caspase-mediated cell death.
Since postpartum psychosis has been linked to activation of the immune system, it has been hypothesized that infectious agents may be involved in the pathogenesis of this disorder.
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