However, in persons in the transitional stage to Alzheimer disease, who have symptoms of MCI, alcohol consumption is linked to accelerated progression toward dementia.
Black carbon, which absorbs heat from the sun, also accounts for anywhere from 10%to45%5% of the contribution to global warming, and is linked to accelerated losses of glaciers in Asia, because the soot deposits darken ice and make it more vulnerable to melting.
Genetically engineered mice in which p53 activity is increased demonstrate that premature loss of neurogenic capacity is linked to accelerated organismal aging.
Loss of miR-34 is linked to accelerated aging and neurodegeneration in Drosophila.
Higher prolactin levels have been linked to accelerated decline in protein levels in term breast milk [ 19, 21].
Our hypothesis is that changes in epigenetic regulation of systemic inflammation and metabolic dysfunction in OSA, are linked to accelerated cardiovascular morbidity.
In contrast, chronic activation of the TOR pathway, which occurs in cases of overnutrition, is linked to accelerated aging and early mortality [ 66].
In support of this notion, symptomatic genital ulcer disease of any etiology has been linked to accelerated HIV disease progression [ 2, 17, 29].
Several products contained ingredients of potential health concern: retinyl palmitate, which has been linked to accelerated development of skin tumors and lesions, was found in 41% of sunscreens assessed, and oxybenzone, an endocrine-disrupting compound, was found in 60%.
p53 gain-of-function mutations are linked to accelerated ageing and premature death in mice [ 99] and humans [ 100], whereas a dominant negative p53 transgene increases longevity in Drosophila [ 101] and loss of function mutations of the C. elegans p53 ortholog cep1 extends life span [ 102].
