Together, these reports suggest that the repair pathway of α-dA and α-dT is conserved among species and that α-dG and α-dC are likely substrates for the same repair pathway.
Previously we showed that GRK2 regulates endothelin (ETA) receptor desensitization, suggesting that ETARs are also likely substrates for arrestin recruitment in MSMCs.
Based on these observations, we speculate that NADH and ADP-ribose are likely physiological substrates for AtNUDT7 or these metabolites may confer stability to this protein.
Telomerase does not act on every telomere in every cell cycle, rather telomerase is activated stochastically with short, rather than long, telomeres being the most likely substrates for telomere extension (Teixeira et al, 2004; Chang et al, 2007).
Since HVC-RA connections are a likely substrate for song learning, having an abundance of these connections, as is the case during the height of sensorimotor learning, means that the learning system has a relatively large number of connections to explore and modify.
This suggests that both RasG and RasS are involved in macropinocytosis (and likely substrates for NF1), but act redundantly.
While this class of molecules is not a likely substrate for UBIAD1, they may be ligands that are transferred to protein binding partners.
Electron-rich molecules like azo dyes are likely to be substrates for oxidative enzymes like Peroxidase and Laccase (Vijaykumar et al. 2006).
However, the fact that linoleic acid (C18∶2 n-6) is not decreased in either liver mitochondria or whole tissue [26] indicates that 20 carbon n-6 fatty acids, such as arachidonic acid (C20∶4 n-6), are likely the primary substrates for n-3 fatty acid synthesis.
As anthranoid laxatives are also 'natural products' and chemically related to anthracyclines they are likely to be substrates for MDR mechanisms.
