Indeed, mouse tRNASec knock-outs have been shown to be lethal in-utero [16].
As the sw gene is lethal in some conditions but not in others – sw mutants specially need managing conditions to develop – we suggest that they are the cause of the lack of F2 adjustment in some families such as 61.
In the vast majority of patients, the condition resolves with minimal or no therapy, although it is lethal in some cases.
First, strains lacking the decapping enzyme grow very slowly or are lethal in some strain backgrounds (Beelman et al. 1996; Dunckley and Parker 1999; Giaever et al. 2002), while strains defective in cytoplasmic 3′ to 5′ mRNA degradation grow relatively normally (Anderson and Parker 1998; Giaever et al. 2002).
Obviously, there must be accumulation of some mutations that would be lethal in clonal replication, but not others, so the meaning of "replication deficit" is quite unclear.
The damage that Adair has done to Politifact's credibility will be lethal in many quarters.That's a pity, because it has done some excellent work.
The colitis is atrocious, and would be lethal in almost everybody.
Failing to deliver health information messages could be lethal in a real emergency.
Those issues, touchy in the party fight, are likely to be lethal in a general election.
