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6, 14– 19 When these FDG-avid tumors were correlated with histology, they tended to be less well differentiated and had more aggressive histological features.
Again, an implication here is that these cells might be less well differentiated than densely ciliated cells and may possibly lack in vivo control mechanisms; Some statement acknowledging (or refuting) this possibility should be added to the Discussion.
We hypothesized that ITC detected by FDG-PET/CT might have more aggressive histological features than those detected by other means, as previous studies have shown that primary nonincidental carcinomas as well as their metastases detected by FDG-PET/CT tended to be less well differentiated, possessed more aggressive histological features, and behaved more aggressively.
As cell loss increased, tumour thymidine labelling index (TLI) increased and the tumours tended to be less well differentiated.
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That is because the smaller cells are less well differentiated (Fine and Hilgemann, Am J Physiol Cell Physiol. 2013 305 C481-91), and that is why pump current densities are lower in the GFP-transfected myocytes.
Whether sparsely ciliated cells are less well differentiated or represent a subclass of ciliated ependymal cells is unclear, but the low abundance of CaV channels revealed by patch clamping of these cilia is consistent with a cytoplasmic control of ciliary [Ca2+] in imaging experiments from multiciliated cells.
Cancer cells also tend to be less-well-differentiated than normal cells, a characteristic that is called anaplasia.
While the cell lines shared many morphological and biochemical characteristics, those derived from recurrences and metastases appeared to be less differentiated, were less well organized in culture, and displayed fewer desmosomes and tonofilaments than cells in the primary tumour line.
While many studies have focused on functions of the Shh signaling pathway on neural progenitors, its function in differentiated neurons is less well understood.
Europe is less well endowed.
Tumours tend to be larger, less well differentiated, more likely to be lymph-node positive and more likely to metastasise compared to tumours found in older women.
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