AAV vectors have a good safety profile, and are less immunogenic compared with other viruses, although antibodies do develop against AAV capsid proteins that can compromise repeat administration.
Human or humanised monoclonal antibodies are preferred for targeting applications, as they are less immunogenic compared with rodent or chimeric antibodies (Hale et al, 1988; Winter et al, 1994).
This result may be a particular issue where accelerated schedules, such as the UK 2,3,4-month schedule, are employed because such schedules may be less immunogenic when compared to extended schedules (19 ).
Poor vaccine immunogenicity is a problem for mucosal vaccines such as OPV and rotavirus both of which have proved to be less immunogenic in poor compared to wealthier populations [ 9, 10, 68, 69].
Although such antibodies were proved to be less immunogenic, they frequently exhibited reduced affinity compared to the parent murine antibody.
"There's a suspicion that it might be less immunogenic than whole inactivated virus," Barouch concedes.
While more tolerable, subunit vaccines tend to be less immunogenic.
Compared with mature cells, fetal cells typically proliferate more rapidly, are more plastic in their differentiation potential, frequently produce more angiogenic and trophic factors, tend to be less immunogenic, can survive at lower oxygen tensions, commonly lack strong intercellular adhesions, and display better survival after refrigeration and cryopreservation protocols.
While ER + disease appears to be less immunogenic than HER2+ and triple negative breast cancer, it displays the greatest degree of heterogeneity.
However, our study could not rule out that DbpB may be less immunogenic than DbpA during borrelial infection.
