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Inbred individuals are expected to be less fit than outbred individuals because of increased homozygosity at genetic loci influencing fitness (Slate et al. 2000), and populations with low genetic variation appear less able to adapt to changes in environmental conditions, including exposure to different physical and chemical stressors (Brown et al. 2009).
Those runners, who tend to be less fit, are hurt even more by a fast start, he added.
The more offspring one has, particularly at one time, the more likely that some of them, at least, will be less fit.
Subsequently, strains carrying these elements may be less fit to survive in a competitive environment with faster growing wild type strains once antibiotic therapy is discontinued.
Furthermore, Mycobacterium tuberculosis strains resistant to rifampicin and INH might be less fit than drug susceptible strains and therefore lead to longer duration of disease with less mortality [15].
At the very least, it becomes ethical not to help those humans deemed to be less fit.
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Turing was certainly an exceptional man but the tribute could not be less fitting.
You see, we are Persian (aka Iranian), and by virtue of not being either Jewish or Christian we are classified as "Muslim" -- though the classification could not be less fitting.
K103N + L100I had a greater reduction in fitness and was less fit than K103N + V108I and K103N + P225H.
These programs "get rid of the intimidation factor -- women are going where they will see a woman who is more fit and a woman who is less fit," said Dr. Callahan, the author of "The Fitness Factor" (Lyons Press, 2002).
"We know kids today are less fit," Mr. Palkoska said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com