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Atovaquone has also been used in the treatment of PCP, and is reported to be less efficacious but better tolerated when compared to TMP- SMX.
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Compared with CPAP, the gold standard therapy, OAs are less efficacious but are more accepted and tolerated by patients, which, in turn, may lead to a comparable level of therapeutic effectiveness.
Abatacept is expected to be less efficacious than tocilizumab, but showed findings comparable to all other biologic agents.
These agents appear to be less efficacious than dopamine agonists, but are better tolerated.
Therefore, the addition of capecitabine to MMC may be less efficacious than these combinations, but is associated with a more acceptable toxicity profile.
Antigen-sparing vaccines have the most potential to increase population coverage but may be less efficacious.
Third party donor-derived CTLs might be expected to be less efficacious than fully HLA-matched CTLs, but the outcomes from this bank, as well as other centres (Doubrovina et al, 2012), have reported broadly similar outcomes to the use of autologous cells.
In contrast, cosmetic antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin.
These are not only believed to be associated with minimal risk of toxicity but are also expected to be less efficacious than the higher doses that may be used later in the trial.
Colonoscopy may be less efficacious in reducing colorectal cancer mortality in the proximal compared with the distal colon.
Counter-intuitively, there are situations in which earlier inoculation can be less efficacious, and simultaneous inoculation with antibiotics can be detrimental.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com