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Additional target site conservation analyses revealed short seeds to be less conserved than long seeds.
Notably, the protein protein interface in this homodimer was found in another study (Caffrey et al., 2004) which used multiple sequence alignment of this protein's sequence homologues to determine the extent of conservation of its surface residues, to be less conserved than the rest of the exposed surface.
Although novel TUs appeared to be less conserved than annotated genes distributionally, more than 20% of them exhibited very conserved mean phastCons scores, especially those supported by polyA reads and EST alignments.
The loop regions of GPCRs tend to be less conserved than the TMH regions and in some cases are structurally diverse in the available GPCR structures e.g. ECL2.
Interologs, however, were found to be less conserved than orthologs [12], and less reliable than interactions generated by high-throughput (HTP) approaches [13].
HLA alleles with a high RH, on the other hand, prefer proline (P) at position 2, which is coded by 4 triplets, and is known to be less conserved than tryptophan.
Similar(41)
The small fraction is highly conserved, while the longer fraction is less conserved than typical exons but more than intergenic or intronic sequences.
We found that our predicted novel cleavage stage lncRNAs are less conserved than protein coding transcripts, but have similar conservation to pre-annotated lncRNAs.
Qu and Adelson [ 34] concluded from their comprehensive evaluation of available lncRNA-related studies across species that lncRNAs are less conserved than protein coding genes but still exhibit a clear conservation compared to non-functional genomic elements.
Just as the gene order is less conserved than that in Mytilus species, Crassostrea species exhibit lower conservation of amino acid identity in all protein-coding genes (Table 2).
However, a recent analysis of the residue conservation in the protein interfaces showed that the charged residues are less conserved than hydrophobic or aromatic residues [48].
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