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Despite addressing the toxicity issues, inhibitors of ABC transporters have proved to be largely disappointing in clinical trials.
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Epidemiological studies suggested that long term use of non-steroidal anti-inflammatory drugs (NSAIDs) has a protective effect in progression to AD, but recent large randomized clinical trials, using predominantly COX-2 selective drugs, have been largely disappointing and have not shown any improvement in memory function of AD patients (Aisen, 2002).
Initial training efforts were largely disappointing for those with ASD, suggesting an intractable deficit.
However the results of combining these agents with chemotherapy and radiation have been largely disappointing.
While the 2010 election was largely disappointing for New York Republicans, there was a silver lining.
Much like this shortened season, these playoffs have thus far been largely disappointing.
Messi's vote appeared to be entirely based on his club form as his performances for Argentina, under coach Diego Maradona, were largely disappointing.
But in the 10 years since the first human experiment was conducted by researchers at the National Institutes of Health in Bethesda, Md., the results have been largely disappointing.
Feilhaber's breakthrough hopefully signals a sign of things to come from a player that has been largely disappointing this season.
- Siraj Datoo Although the PlayStation 4 and Xbox One launch games were largely disappointing, 2014 will certainly see both machines move up a gear.
Even more challenging to the "oxidative stress theory of neurodegeneration" is the fact that many antioxidant-based clinical trials and therapeutic interventions have been largely disappointing in their therapeutic benefit.
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