Sentence examples for be largely abrogated from inspiring English sources
These results suggest that (1) the signal for HSP26 synthesis can be largely abrogated by elevated Ca2+ binding protein levels, and (2) if these HSPs are involved in thermotolerance development, that function may be associated with intracellular Ca2+ homeostasis.
In Wilm's tumor, the stem cell properties of sphere formation and clonogenicity can be largely abrogated after the application of anti-FZD7, antibodyody for Wnt receptor Frizzled 7 [48].
BLC-supernatant dramatically induced death of HCC-cells, which could be largely abrogated by preincubating the supernatant with TNF β-antiserum.
The effect of MF-2 and MF-6 supernatant could be largely abrogated by pre-incubation with neutralising anti-HGF, whereas anti-HGF was without effect on the BLC-supernatant (data not shown).
However, this difference was largely abrogated by addition of anti-CD28 (Fig. 3c,d), indicating that a strong co-stimulatory signal through CD28 overrides the enhanced TCR response in Cic-deficient T cells.
Correlating with these findings, while we found that the crizotinib ALK binding in RU cells was largely abrogated upon the enforced expression of β-catenin-wt, transfection of ΔN47 into RU cells did not substantially affect the crizotinib ALK binding (Fig. 5C).
However, these activities were largely abrogated for FGF19v (Fig. 2D, E and F).
Therefore, we blocked TLR2 on keratinocytes using antibodies prior to chitin treatment and found that the chitin-induced effects were largely abrogated when TLR2 was blocked (Table S1).
Based on these previous findings that chitin might be sensed through TLR2, we blocked TLR2 and found that the chitin-mediated effects were largely abrogated.
In hepatocytes (O cells) with the HCV replicon, however, DDX3/IPS-1-enhanced IFN-beta-induction was largely abrogated even when DDX3 was co-expressed.
The HCV RNA of O cells had a high potency to induce reporter activation, and this activity was largely abrogated by si-1 siRNA treatment.
