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Second tumours were more likely to be large or node-positive if the first breast cancer had these features.
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Table 4 summarises multivariate analysis of the features of the first cancer that predicted these features in the second tumour: women whose first cancer was large or node positive at diagnosis were more likely to have large or node-positive second cancer.
Similar to a previous case control study (Wohlfahrt et al, 1999), we found that delayed age at first full-term birth was associated with increased risk of tumours that were large or node positive, whereas multiparity was associated with reduced risk for small tumours.
Survival was poorest when the second cancer was large (HR=2.26) or node-positive (HR=3.43), when the time between the two diagnoses was <5 years (HR=1.45), or when the diagnosis was in an earlier epoch (HR=2.20).
Cyclooxygenase-2-positive tumours tend to be larger, higher grade, node-positive and HER-2/ neu-positive.
However, large or node-positive second tumours, and shorter intervals between diagnoses were indicators of poorer survival.
Furthermore, of the cancers detected at the first round of screening, the youngest age of diagnosis of a large (>2 cm) or node-positive cancer was 48 years.
The Cox model indicates that second cancers that were 2 cm or larger or node positive had a poor prognosis.
Despite this, no detriment to long-term survival was found in either node-negative or node-positive patients.
Patients in these subgroups tended to be younger with larger, node-positive, and high-grade tumors.
Patients in the HER2-like and Basal-like subgroups tended to be younger with larger, node-positive, and high-grade tumors.
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