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Bad and Caspase-9 are thought to be key regulators of cellular apoptosis whose activity is regulated, in large part, by Akt phosphorylation [ 25, 40, 41].
In these animals, the circadian clock-regulated hormones melatonin and prolactin are thought to be key regulators of seasonal changes in hair growth [ 31- 34].
They have been shown to be key regulators of proteins associated with pharmacokinetics.
Nearly all of the genes known to be key regulators of the circadian clock were first identified in flies.
The VEGF isoforms 121 and 189 may be key regulators of increased vascularity and progression of hepatocellular carcinoma, one of the most common malignant tumors, and may be of prognostic significance for this tumor.
Combining data from gene expression, proteomics and studies in other systems, we propose that DNAJ will be key regulators of cancer, stem cell and possibly cancer stem cell function.
Thus, c-ETS transcription factors appear to be key regulators of MCM4 origin where c-ETS2 seems to promote DNA replication whereas c-ETS1 functions as a negative regulator.
Increasing evidence has indicated that miRNAs, in fact, may be key regulators of various fundamental biological processes.
Small G proteins are believed to be key regulators of the cytoskeleton.
Both MeCP2 and EZH2 have recently been shown to be key regulators of Pparg repression [22].
KLKs are capable of cleaving corneodesmosomes [7] [10] and are thought to be key regulators of the desquamation process.
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CEO of Professional Science Editing for Scientists @ prosciediting.com