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Encouragingly effect sizes approaching or at the moderate level were also seen in several parental variables which may be key mediators of children's EM use (mediation was not tested due to small sample size) [ 45].
Substrates such as p120, Hrs, Ack, p130Cas and FRK may be key mediators of SRC signaling in human tumors and contribute directly to SRC-mediated events during tumor progression.
Interestingly, all three genes could inhibit the p53-mediated induction of BAX and PIG3, which are known to be key mediators of mitochondrial apoptosis and the DNA damage response pathway, respectively [ 3].
This is an important consideration since MZBs express high levels of CD21 and may be key mediators of C3d function [37], [38].
In skin infection, migratory DC (such as Langerhans cells and dermal DC) have long been thought to be key mediators of T cell immunity.
In the case of pathogenic Leptospira species, OMPs would be key mediators of the adaptation and response to changes in environmental conditions inside and outside of the host during their life cycle.
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Adsorbed proteins are key mediators of cell behaviour.
Thus, cytoskeletal tension and cellular force generation are key mediators of the activation of TGFβ signaling.
Type I interferons (IFNs) are key mediators of the innate antiviral response in mammalian cells.
Eukaryotic initiation factor 2 alpha kinases (eIF-2α kinases) are key mediators of stress response in cells.
Selumetinib, was developed by AstraZeneca is an oral, selective non-ATP competitive inhibitor of MEK1/MEK2, which are key mediators of KRAS signaling (Fig. 1) [32].
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