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He will be irreplaceable in the lives of all who knew him.
It is imperative for the Premiership season that he is retained as he would be irreplaceable in the January transfer window, especially since very little, if any, of the transfer fee would be available for reinvestment.
In birds, β-keratin gene family expansion may have replaced some important roles of α-keratins during the formation of hard appendages, so that the remaining avian α-keratins might be irreplaceable in the formation of their skin appendages (Ng et al. 2012).
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These permafrost carbon stocks are irreplaceable in the current climate.
For these reasons, hemlocks are irreplaceable in the landscape, and their loss would render our forests unrecognizable.
It's the wisdom of physicians that is irreplaceable in the continuum of care.
The Illustrated Sporting and Dramatic News lamented Barrington's departure, suggesting that he was irreplaceable in the Savoy Operas: "He is the typical embodiment... of that British Philistinism, the pachydermatous hide of which Mr. Gilbert has so long striven to penetrate by the process of holding up its own image before it".
Nevertheless, the role played by a potential participant's autonomy and the principle of informed consent are irreplaceable in the ethics of clinical research.
However, their usage in resource-constrained countries is still hampered by high cost and difficulties in testing for high throughput screening and thus laboratory-based immunoassays would be irreplaceable in many fields.
To architecture fans, the watercolors are irreplaceable in showing the original appearance of the structures and their broader setting in Napoleon's time.
What is new is the dawning awareness that circulatory arrest is a mechanism of death and not in itself a philosophical concept of death; that cessation of the heartbeat is only lethal if it lasts long enough to cause critical centres in the brain stem to die; and that this is so because the brain stem is irreplaceable in a way the cardiac pump is not.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com