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Nodal metastases were considered to be involved with tumour if they demonstrated positive tracer uptake on FDG-PET scans.
We speculate that ApoC-II levels may be involved with tumour progression.
Interestingly, Kaminski reported that in a number of patients who relapsed following RIT the relapse occurred only at sites previously not known to be involved with tumour [ 101]; this indicates a possibility that small tumour manifestations receive lower absorbed doses than expected on the basis of antigen density and tumour diameter [ 102].
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In fact, the external iliac vessels and obturator space were involved with tumour that we considered as nodal involvement.
The sentinel node was involved with tumour in 38 patients, resulting in a false negative rate of 5% (2/40).
For example, when more than 50% of biopsy cores were involved with tumour, we found that most of these tumours (>95%) were multifocal.
Multivariate analysis identified only limited tumour pattern, defined as 4 or less IMO fields being involved with tumour, to be protective against surgical morbidity (HR=0.082; 95% CI: 0.011 0.61; P=0.015).
This may suggest that tumor cells were shed during surgical manipulation of the tumour, however the surgical margin was involved with tumour in both cases and there was evidence of extracapsular spread in Patient 10.
However both bladder neck and prostatic fossa proximal to the prostatic utricle were involved with tumour at initial resection and these areas were consequently extensively resected with loop diathermy.
Venography to examine the inferior vena cava and hepatic veins is occasionally useful if all three major hepatic veins are involved with tumour as an adequate inferior or middle right hepatic vein may obviate the need for ex-vivo venous reconstruction[ 2, 3].
Results of this study demonstrated that Lck is expressed within the tumour, providing evidence that Lck itself may be involved with signal transduction in the tumour.
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