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Click on a gene's description to view its network relationships with genes known to be involved in "synaptic vesicle endocytosis".
While scientists don't yet know the exact function of the gene, it may be involved in synaptic plasticity, a form of cellular learning.
Given the pattern of changes in hippocampal structure and function, one potential target for these effects is the ethanol sensitive GluN2B subunit of the NMDA receptor, which is known to be involved in synaptic plasticity and dendritic morphology.
Recently, GSK-3β in synapses have been reported to be involved in synaptic plasticity [20].
Specific neurexins' transcripts may be involved in synaptic remodeling occurring at an intermediate (hours) time scale in the course of memory formation.
The sec6 gene encodes a protein that is homologous to a mammalian sec6 protein, and it is predicted to be involved in synaptic vesicle recycling [26].
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A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
In particular, a large number of genes implicated in ASD and other neurodevelopmental disorders are involved in synaptic function and chromatin modification.
The researchers turned to Beth Stevens, an assistant professor of neurology at Boston Children's Hospital and Harvard, who was an author of a 2007 study showing that the products of MHC genes were involved in synaptic pruning in normal developing brains.
These cell surface proteins are expressed by healthy neurons and are localized at the synapse, where they are involved in synaptic transmission and plasticity, two fundamental features of learning and memory.
They have a unique modular architecture with four domains: the intracellular C-terminal domain (CTD) that is involved in synaptic targeting, the transmembrane domain (TMD) that forms the ion channel, the membrane-proximal ligand-binding domain (LBD) that binds agonists such as L-glutamate, and the distal N-terminal domain (NTD), whose function is the least clear.
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