Sall1 expression in the digital plate could be involved in patterning the digit 2 condensation although it should be noted that Sall1 is also highly expressed throughout the Sox9 expressing condensation for digit 3.
Preliminary experiments with inhibitors of the Wnt and fibroblast growth factor pathways suggest that these may be involved in patterning the pilidium (Hiebert, unpublished).
A pair-rule segmentation oscillator underlies the generation of all anterior trunk segments, and may also be involved in patterning of head segments from the intercalary back.
However, the downstream cytoplasmic partners of the transmembrane proteins shown to be involved in patterning in melanophores and xanthophores are unknown as well as transmembrane molecules in iridophores that are responsible for the interactions.
In contrast, ClpostHox expression is found in a broad posterior domain that includes ectodermal, endodermal and, possibly, mesodermal cells suggesting that it may be involved in patterning more than just the nervous system.
However, while these studies link FGF signalling to ECM composition and cell migration, they do not address how ECM could be involved in patterning the embryonic axis or induction of specific cell types during ESC differentiation.
As immature neurons are thought to be involved in pattern separation (Clelland et al., 2009; Sahay et al., 2011; Nakashiba et al., 2012), it is possible that BDNF is interacting with these immature neurons during the pattern separation process; however, this idea remains to be tested.
Among these, the highly significant genes (FDR <10%) genes were selected that are involved in pattern recognition signaling, antiviral signaling and experimentally identified Nrf2 transcriptional targets51,52,53.
The research in her laboratory focuses on on cell to cell signaling processes that are involved in pattern formation during development, using Drosophila as a model system.
Many of the genes for brain development are involved in patterning and building the cortex, a process that starts in the first trimester of fetal life when brain cells, or neurons, are born in a region lining the cerebral cavity.
