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While Mandel and colleagues interpret their results in terms of normal aging as opposed to AD pathology, our findings tentatively suggest that this mechanism may also be involved in pathological ageing associated with a known CSF biomarker for AD, as well as a known genetic predisposition for the disease.
These cells may be involved in pathological processes mainly producing pro-inflammatory cytokines.
Spinal cord immune (i.e., glia) cells have been shown to participate in pain enhancement as part of the adaptive sickness response; thus, they could be involved in pathological pain states.
There is major interest in designing inhibitors for matrix metalloproteinase 2 (MMP-2, gelatinase A) since this enzyme is known to be involved in pathological processes such as tumor invasion or rheumatoid arthritis.
IMAC or PtP may be involved in pathological propagation of ROS production and mitochondrial activation in skeletal muscle.
Disturbances in this process may be involved in pathological conditions such as pre-eclampsia and intra-uterine growth retardation [3], [4].
Similar(42)
This process is involved in pathological conditions such as vascular remodeling or ischemia reperfusion injury.
Interestingly, M2 macrophages have been involved in pathological settings such as tumor progression, parasitic infection and respiratory disorders.
EGFR and VEGFR-2 are involved in pathological disorders and the progression of different kinds of tumors, the combined blockade of EGFR and VEGFR signaling pathways appears to be an attractive approach to cancer therapy.
PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least by controlling extracellular proteolysis and by regulating endothelial cell survival and migration.
MAPK signaling has been shown to be required for BMP physiological effects such as developmental patterning and organogenesis or apoptosis and is involved in pathological events such as aberrant epithelial-mesenchymal transition, tumor progression and invasion [19], [27], [42] [43].
More suggestions(17)
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