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Of these 142 predicted secretory proteins, 21 were reported to be involved in pathogen virulence or pathogenicity (Table 6).
The fact that several receptors may be involved in pathogen recognition renders the system more robust against immune evasion by the pathogenic microbe.
WAKs, LRR receptor-like serine/threonine-protein kinases, LRKs can be involved in pathogen resistance and abiotic stress response (Afzal et al. 2008; Kanneganti and Gupta 2008; Vaid et al. 2013).
Studies have indicated that some WAKs may be involved in pathogen defense responses.
Prior studies of Bd gene expression throughout development identified the differential expression of several genes with sequence similarity to genes thought to be involved in pathogen evasion of vertebrate immune systems [35], but further research is necessary to evaluate which Bd secreted proteins may interact with the host immune system.
Interestingly, following rosiglitazone treatment, the expression of the MR, Dectin-1, CD36 and TLR-2, receptors known to be involved in pathogen elimination, at the surface of macrophages from mice both in chow and HF fed conditions were significantly higher (Figure 2A).
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Palmitoyltransferases have been reported to be involved in pathogen-induced programmed cell death (Saucedo-Garcia et al. 2011).
Toll-like receptors are likely to be involved in pathogen-derived triggers, and a significant part of their intracellular effects is mediated by activation of the classical pathway of NF-κB [ 109].
Ninety-five of 438 annotated contigs were described as being involved in pathogen virulence or pathogenicity (Table 5).
The Arabidopsis AGO1 is required for Verticillium pathogenicity (Ellendorff et al. 2009), whereas AGO2 is involved in pathogen immunity by binding miR393* in modulating the exocytosis of Pathogenesis-Related 1 (PR1) (Zhang et al. 2011).
Collection data for the larvae of one Aedes species and three species-groups of Anopheles, all of which are involved in pathogen transmission, were used.
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