Sentence examples for be involved in oncogenic from inspiring English sources

One member of the UCH family, UCH L1, is expressed in a number of malignancies suggesting that this DUB might be involved in oncogenic processes, and increased expression and activity of UCH L1 have been detected in EBV-immortalized cell lines.

EZH2 may, however, be involved in oncogenic transformation by attenuating DNA repair, thereby increasing genomic instability [ 39].

Recently, Msi1 expression has been detected in human gliomas and melanomas, indicating it may be involved in oncogenic development.

SV40-T antigens are known to be involved in oncogenic transformation through interference with many cellular processes.

Sunitinib also inhibits KIT, FLT3, CRF1R, and RET, which are known to be involved in oncogenic signaling in different malignant tumor entities.

Also, none of their physiological target genes has been found to be deregulated in Maf-transformed cells or to be involved in oncogenic processes (Eychene et al, 2008).

Indication that mTOR signaling is involved in oncogenic transformation stemmed from studies of Akt mutants with kinase activity but failed to phosphorylate p70S6 kinase and 4EBP1.

In the nucleus, the β-catenin-TCF/Lef complex activates target genes such as c-Myc and cyclin D1, which are involved in oncogenic transformation [4], [20] [26].

The increased concentration of β-catenin in the cytoplasm favors its binding to the T-cell factor (TCF) family of DNA-binding proteins [17], and it subsequently translocates to the nucleus where it induces transcription of specific genes which are involved in oncogenic transformation [20] [30].

Our results offer mechanistic insights into breast tumorigenesis, suggesting that methylation of MT1 gene cluster is involved in oncogenic events.

CD44 proteoglycans and P2X7 receptors are involved in oncogenic processes and most malignant tumors do overexpress them.