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Importantly, this study suggested that amplification of COT in melanoma cell lines may also be involved in de novo resistance.
We acknowledge that it is possible that different mechanisms may be involved in de novo docetaxel resistance.
Using this data we identified unigenes that may be involved in de novo FA and triacylglycerol biosynthesis.
Using this data we identified 388 unigenes that may be involved in de novo fatty acid and triacylglycerol biosynthesis.
In ER/PgR-positive disease, activated Src kinase does not appear to be involved in de novo endocrine resistance.
The chromosome of the lithoautotrophic bacterium Ralstonia eutropha H16 also contains a thiCOSGE locus that is proposed to be involved in de novo synthesis of thiamine [ 67].
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Hence, we hypothesized that Ash1L might be involved in de-repression of 4q35 genes.
The other substrate for resveratrol synthase, malonyl-CoA, is already found in yeast and is involved in de novo fatty-acid biosynthesis.
DNMT3A and -3B are involved in de novo methylation, establishing tissue-specific DNA methylation marks during development [26], [27].
This makes sense as hydrocortisone and dexamethasone are involved in de novo synthesis of ANXA1 gene (Mulla, A, et. al, 2005).
As many of these proteins are involved in de novo synthesis processes, this may indicate some extension of the self-sustenance of ES cells and germ cells.
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