PTBP1 and SRSF1 are two splicing factors known to be involved in cancer.
He said another gene, cyclin-dependent kinase inhibitor 2A, seemed to be involved in cancer, diabetes and heart disease.
HMGB1, an important nuclear protein, is known to be involved in cancer development and is associated with drug resistance in tumor cells31,44,45,46.
Cysteine Cathepsins well known to be involved in cancer, inflammation and regulation of degenerative processes like apoptosis have become specific targets in drug designing.
Besides, autophagy was found to be involved in cancer formation and progression.
Already proven to be involved in cancer and aging, tau protein accumulation is known to exist in 20 human brain diseases.
Interestingly, RNASET2 has been shown to be involved in cancer suppression and loss of function mutation causes cystic leukoencephalopathy (Acquati et al., 2011; Henneke et al., 2009).
The Piwi-piRNA pathway is important for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control and thus may be involved in cancer development.
SREBP proteins are central for maintaining cellular lipid homeostasis, and unusual activation of SREBPs can contribute to obesity, fatty liver disease, insulin resistance, and could also be involved in cancer development [83].
However, all of the SERPINB genes that appear to be involved in cancer etiology localize together to 18q21 [24].
