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"I just can't believe that they would engage in the economic sabotage that would be involved in blocking this deal.
On the other hand, two remarkable domains are included in the NS5A region: the V3 domain, seemingly involved in responsiveness to interferon [70], [84], and PKR-BD, which contains the putative interferon sensitivity determining region (ISDR) and seems to be involved in blocking the cellular antiviral response induced by interferon [61], [85] [87].
However, knockdown of the ND10 proteins is not enough for MCMV to productively infect human cells because no viral particles can be detected in the human cell; some other mechanism must be involved in blocking the successful infection of MCMV in human cells.
The repetitive elements seem to be involved in blocking replication initiation in the subtelomeric regions [ 20– 22], and favoring their nuclear-periphery localization [ 20, 23].
That similar mechanisms could be involved in blocking IFN-γ-activated pathways (e.g., STAT1 trafficking) would be an intriguing area for future research.
This observation suggests that the accumulation of RNAPII molecules itself at the Tsix 3'-end could be involved in blocking the spreading of H3K27me3 from the hotspot to within Xist/ Tsix.
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We are also curious whether any nuclear structure (and its components) is involved in blocking cytomegalovirus cross-species infection.
Future studies will focus on identifying the additional mechanisms that are involved in blocking cross-species infection.
Finally, CD26/dipeptidyl peptidase IV (DPIV) is a serine protease responsible for the cleavage and inactivation of chemokines such as RANTES and SDF-1, which are involved in blocking HIV entry [69], [70].
In addition, we show that ND10 colocalizes with IE1 in cross-species infections but is not dispersed by CMV in such infections (HCMV in mouse cells and MCMV in human cells) and that ND10 components are involved in blocking viral gene expression in both MCMV and HCMV cross-species infections.
For instance, we discovered that intrinsic cellular defense mechanisms are involved in blocking MCMV infection in human cells and that these mechanisms can be overcome by HCMV-encoded proteins (such as immediate-early protein 1 IE1), resulting in successful cross-species infection [7].
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