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These repeats appear to be involved in binding carbohydrates; for example, the chicken teneurin-1 YD-repeat region binds heparin.
Further mutational analysis showed that a nearby open cavity may also be involved in binding specificity to HBGAs.
Surprisingly, growth stimulation was not observed in vitronectin-coated plates, suggesting that integrins other than αvβ3 could be involved in binding of the recombinant peptide, maybe as coreceptors.
The model suggests that Gln45 and Tyr49 mediate their effects by interacting with RAMP1 whereas Leu41 and Ala44 are likely to be involved in binding CGRP.
The N-terminal sequence of the Smac/DIABLO protein is known to be involved in binding to the BIR3 domain of the anti-apoptotic proteins IAPs, antagonizing their action.
A structural analysis of these proteins found that the two amino acids are located in positions on the molecule where they could be involved in binding to host cell receptors.
These regions may potentially be involved in binding of a second adaptor, for example TRIF.
These arginines may be involved in binding to the negatively charged phosphates of DNA.
Most of these residues were also predicted to be involved in binding of bradykinin.
The domain of hZW10 required for hZwint-1 interaction may therefore be involved in binding at the spindle pole.
EHD1 regulates transport of β1 integrin [21] and EHD4 has been reported to be involved in binding to ECM [22].
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