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Using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways database in DAVID we also observed a significant enrichment for genes involved in the signaling pathways for pyrmidine and purine metabolism, as well as for genes known to be involved in base excision repair (Table 2).
Analogously to ALKBH2, ALKBH3 also contains a flexible hairpin that is thought to be involved in base flipping and distinguishing single-stranded versus double-stranded substrates.
Polδ has been shown to be involved in base excision repair (Blank et al. 1994), repair of UV-damaged DNA (Torres-Ramos et al. 1997), and template switching after DNA damage occurs (Vanoli et al. 2010).
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We collected from the Human DNA Repair Genes database (Wood et al, 2001, 2005), all the genes known to be involved in base-excision repair, mismatch-excision repair, nucleotide-excision repair, homologous recombination and nonhomologous end joining.
These contractors are involved in Base Support, Construction, Translator/Interpreter, Security, Transportation, and Communications Support functions.
In order to quantify the openness of RNA, we used a sliding window length of 7 bases to estimate the fraction of simulated structures in which none of the bases in that window were involved in base pairing.
The MUTYH gene is involved in base excision repair.
Three genes are involved in base excision repair (BER), and they are mutT, nfo, and polB.
The first two stem-loops are involved in base pairing with the mRNA targets.
XRCC1 is involved in base excision and single-strand break repair (Whitehouse et al. 2001).
While PARP1 is involved in base excision repair occurring in response to DNA damage [ 9], BARD1 functions in association with BRCA1 [ 10].
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CEO of Professional Science Editing for Scientists @ prosciediting.com